2022
Koopman MB, Ferrari L, Rüdiger SGD, Berghoff SA, Spieth L, Saher G, Stacho M, Manahan-Vaughan D, Shrestha P, Klann E, Cisneros J. 254 Dopamine ramps for accurate value learning under uncertainty. Neurosciences 2022 45:0166-2236.
Garfagnini T, Ferrari L, Koopman MB, Halters S, Van Kappel E, Mayer G, Maurice MM, Rüdiger SGD, Friedler A. A peptide strategy for inhibiting different protein aggregation pathways in disease. BioRXiv 2022 Link
Koopman MB, Ferrari L, Rüdiger SGD. How do protein aggregates escape quality control in neurodegeneration?. Trends in Neurosciences. 2022 45:257-71 Link
2021
Jarosińska OD, Rüdiger SGD. Molecular Strategies to Target Protein Aggregation in Huntington’s Disease. Front. Mol. Biosci. 2021 8:1068 Link
Lashley T, Tossounian MA, Heaven NC, Wallworth S, Peak-Chew S, Bradshaw A, Cooper JM, de Silva R, Srai SK, Malanchuk O, Filonenko V, Koopman MB, Rüdiger SGD, Skehel M, Gout I. Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A. Front. Cell. Neurosci. 2021 15:411 Link
Dekker FA and Rüdiger SGD. The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease. Front. Mol. Biosci. 2021 8: 697913 Link
Aragonès Pedrola J, Rüdiger SGD. Double J-domain piloting of an Hsp70 substrate. J. Biol. Chem. 2021 100717 Link
2020
Bhattacharya K, Weidenauer L, Luengo TM, Pieters EC, Echeverría PC, Bernasconi L, Wider D, Sadian Y, Koopman MB, Villemin M, Bauer C, Rüdiger SGD, Quadroni M, Picard D. The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nat. Comm. 2020 11:1-21 Link
Koopman MB, Rüdiger SGD. Alzheimer cells on their way to derailment show selective changes in protein quality control network. Front. Mol. Biosci. 2020 fmolb.2020.00214 Link
Koopman MB, Rüdiger SGD. Behind closed gates–chaperones and charged residues determine protein fate. EMBO J. 2020 e104939 Link
Weickert S, Wawrzyniuk M, John LH, Rüdiger SGD, Drescher M. The mechanism of Hsp90-induced oligomerizaton of Tau. Science Adv. 2020 11:eaax6999 Link
Ferrari L, Stucchi R, Konstantoulea K, van der Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun. 2020 11:571 Link
Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R & Hiller S. Regulation of α-synuclein by chaperones in mammalian cells. Nature 2020 577:127-32 Link
2019
Ferrari L, Rüdiger SGD. (2019) Hsp90 Chaperone in Disease. In: Asea A., Kaur P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. Link
Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes G-J, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A. MAP7 family proteins regulate kinesin-1 recruitment and activation. J Cell Biol. 2019 218(4):1298-1318. Link
Morán Luengo T, Mayer MP, Rüdiger SGD. The Hsp70-Hsp90 chaperone cascade in protein folding. Trends Cell Biol. 2019 29(2):164-177. Link
2018
Ferrari L, Rüdiger SGD. Recombinant production and purification of the human protein Tau. Protein Eng Des Sel 2018 31(12):447-455. Link
Radli M, Rüdiger SGD. Dancing with the diva: Hsp90-client interactions J Mol Biol. 2018 in press Link
Morán Luengo T, Kityk R, Mayer MP, Rüdiger SGD. Hsp90 breaks the deadlock of the Hsp70 chaperone system. Mol Cell. 2018 70:545-552 (cover story). Link
2017
Radli M, Rüdiger SGD. Picky Hsp90 – every game with a different mate. Mol Cell. 2017 67:899-900 (invited preview). Link
Radli M, Veprintsev DB, Rüdiger SGD. Production and purification of human Hsp90β in Escherichia coli. PLoS One. 2017 12(6):e0180047. doi:10.1371/journal.pone.0180047. Link
2016
Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel R, Kuper I, Richter K, Heck AJR, Boelens R, Vincent JP, Rüdiger SGD, Maurice MM. Axin cancer mutants form nano-aggregates to rewire the Wnt signaling network. Nature Struct Mol Biol. 2016 23:324-32. Link
2015
Hagemans D, van Belzen IAEM, Morán Luengo T, Rüdiger SGD. A script to highlight hydrophobicity and charge on protein surfaces. Frontiers Mol Biosci. 2015 2:56. Link
Sinnige T, Karagöz GE, Rüdiger SGD. Protein Folding and Chaperones. Encyclopedia of Life Sciences (ELS). 2015 Link
Karagöz GE, Rüdiger SGD. Hsp90 interaction with clients. Trends Biol Sci. 2015 40:117-125. Link
2014
Karagöz GE, Duarte AMS, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SGD. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 2014 156:963-974. Link
2013
Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SGD. Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. PLoS One. 2013 8:e77257. Link
Xue B, Romero PR, Noutsou M, Maurice MM, Rüdiger SGD, William AM Jr, Mizianty MJ, Kurgan L, Uversky VN, Dunker AK. Stochastic machines as a colocalization mechanism for scaffold protein function. FEBS Lett. 2013 587:1587-91. Link
2012
Minde DP, Maurice MM, Rüdiger SGD. Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. PLoS One. 2012 7:e46147. Link
Suijkerbuijk SJ, van Dam TJ, Karagöz GE, von Castelmur E, Hubner NC, Duarte AMS, Vleugel M, Perrakis A, Rüdiger SGD, Snel B, Kops GJ. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell. 2012 22:1321-9. Link
Li Y, Karagöz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AMS, Schwartz SJ, Boelens R, Carroll K, Rüdiger SGD, Sun D. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 2012 23:1617-26. Link
Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SGD, Schwamborn K, Schambony A, Maurice MM. Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci U S A. 2012 109:E812-20. Link
Didenko T, Duarte AM, Karagöz GE, Rüdiger SGD. Hsp90 structure and function studied by NMR spectroscopy. Biochim Biophys Acta. 2012 1823:636-47. Link
2011
Minde DP, Anvarian Z, Rüdiger SGD, Maurice MM. Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? Mol Cancer. 2011 10:101. Link
Karagöz GE, Sinnige T, Hsieh O, Rüdiger SGD. Expressed protein ligation for a large dimeric protein. Protein Eng Des Sel. 2011 24:495-501. Link
Katz C, Levy-Beladev L, Rotem-Bamberger S, Rito T, Rüdiger SGD, Friedler A. Studying protein-protein interactions using peptide arrays. Chem Soc Rev. 2011 40:2131-45. Link
Karagöz GE, Duarte AMS, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJR, Boelens R, Rüdiger SGD. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011 108:580-5. Link
Noutsou M, Duarte AMS, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SGD, Maurice MM. Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded. J Mol Biol. 2011 405:773-86. Link
Didenko T, Boelens R, Rüdiger SGD. 3D DOSY-TROSY to determine the translational diffusion coefficient of large protein complexes. Protein Eng Des Sel. 2011 24:99-103. Link
2010
Sinnige T, Karagöz GE, Rüdiger SGD. Protein Folding and Chaperones. Encyclopedia of Life Sciences (ELS). 2010 Link (Updated in 2015)
2009
Tsaytler PA, Krijgsveld J, Goerdayal SS, Rüdiger S, Egmond MR. Novel Hsp90 partners discovered using complementary proteomic approaches. Cell Stress Chaperones. 2009 14:629-38. Link
2008
Rotem S, Katz C, Benyamini H, Lebendiker M, Veprintsev D, Rüdiger S, Danieli T, Friedler A. The structure and interactions of the proline-rich domain of ASPP2. J Biol Chem. 2008 283:18990-9. Link
Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A. Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A. 2008 105:12277-82. Link
Rodriguez F, Arséne-Ploetze F, Rist W, Rüdiger S, Schneider-Mergener J, Mayer MP, Bukau B. Molecular basis for regulation of the heat shock transcription factor σ32 by the DnaK and DnaJ chaperones. Mol Cell. 2008 32:347-58. Link
2007
Mayer S, Rüdiger S, Ang HC, Joerger AC, Fersht AR. Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. J Mol Biol. 2007 372:268-76. Link
2006
Vega CA, Kurt N, Chen Z, Rüdiger S, Cavagnero S. Binding specificity of an alpha-helical protein sequence to a full-length Hsp70 chaperone and its minimal substrate-binding domain. Biochemistry. 2006 45:13835-46. Link
Yu GW, Rüdiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A. 2006 103:1227-32. Link
Sinnige T, Karagöz GE, Rüdiger SGD. Protein Folding and Chaperones. Encyclopedia of Life Sciences (ELS). 2006 Link (Updated 2010 & 2015)
2004
Friedler A, DeDecker BS, Freund SMV, Blair C, Rüdiger S, Fersht AR. Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for “mutant conformation”. J Mol Biol. 2004;336:187-96. Link
2002
Vandenbroeck K, Alloza I, Brehmer D, Billiau A, Proost P, McFerran N, Rüdiger S, Walker B. The conserved helix C region in the superfamily of interferon-gamma/interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK. J Biol Chem. 2002;277:25668-76. Link
Rüdiger S, Freund SMV, Veprintsev DB, Fersht AR. CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci U S A. 2002;99:11085-90. Link
Hansson LO, Friedler A, Freund S, Rüdiger S, Fersht AR. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A. 2002;99:10305-9. Link
Friedler A, Hansson LO, Veprintsev DB, Freund SMV, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S, Fersht AR. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U S A. 2002;99:937-42. Link
2001
Patzelt H, Rüdiger S, Brehmer D, Kramer G, Vorderwülbecke S, Schaffitzel E, Waitz A, Hesterkamp T, Dong L, Schneider-Mergener J, Bukau B, Deuerling E. Binding specificity of Escherichia coli trigger factor. Proc Natl Acad Sci U S A. 2001;98:14244-9. Link
Schaffitzel E, Rüdiger S, Bukau B, Deuerling E. Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins. Biol Chem. 2001;382:1235-43. Link
Brehmer D, Rüdiger S, Gässler CS, Klostermeier D, Packschies L, Reinstein J, Mayer MP, Bukau B. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Struct Biol. 2001;8:427-32. Link
Rüdiger S, Schneider-Mergener J, Bukau B. Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone. EMBO J. 2001;20:1042-50. Link
2000
Rüdiger S, Mayer MP, Schneider-Mergener J, Bukau B. Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch. J Mol Biol. 2000;304:245-51. Link
Mayer MP, Rüdiger S, Bukau B. Molecular basis for interactions of the DnaK chaperone with substrates. Biol Chem. 2000;381:877-85. Link
Mayer MP, Schröder H, Rüdiger S, Paal K, Laufen T, Bukau B. Multistep mechanism of substrate binding determines chaperone activity of Hsp70. Nature Struct Biol. 2000;7:586-93. Link
1999
Mogk A, Tomoyasu T, Goloubinoff P, Rüdiger S, Röder D, Langen H, Bukau B. Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB. EMBO J. 1999;18:6934-49. Link
Knoblauch NT, Rüdiger S, Schönfeld HJ, Driessen AJ, Schneider-Mergener J, Bukau B. Substrate specificity of the SecB chaperone. J Biol Chem. 1999;274:34219-25. Link
Brix J, Rüdiger S, Bukau B, Schneider-Mergener J, Pfanner N. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem. 1999;274:16522-30. Link
1997
Rüdiger S, Buchberger A, Bukau B. Interaction of Hsp70 chaperones with substrates. Nature Struct Biol. 1997;4:342-9. Link
Rüdiger S, Germeroth L, Schneider-Mergener J, Bukau B. Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J. 1997;16:1501-7. Link
1996
McCarty JS, Rüdiger S, Schönfeld HJ, Schneider-Mergener J, Nakahigashi K, Yura T, Bukau B. Regulatory region C of the E. coli heat shock transcription factor, sigma32, constitutes a DnaK binding site and is conserved among eubacteria. J Mol Biol. 1996;256:829-37. Link
Gamer J, Multhaup G, Tomoyasu T, McCarty JS, Rüdiger S, Schönfeld HJ, Schirra C, Bujard H, Bukau B. A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J. 1996;15:607-17. Link
1994
Herdegen T, Rüdiger S, Mayer B, Bravo R, Zimmermann M. Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw. Brain Res Mol Brain Res. 1994;22:245-58. Link