PhD theses


Stories of a Diva – Interactions of the Hsp90 chaperone machinery with client proteins

Martina Rádli, March 2018, Braakman and Rüdiger


CFTR folding and the molecular chaperone Hsp90

Daniel Mesquita da Fonseca, November 2017, Braakman, van der Sluijs and Kleizen

Role of CNPY5 in B cell activation and immunoglobulin production

Naomi Lodder, October 2017, Braakman and van der Sluijs

Re-evaluation of PDI function in mammalian cells

Anna Chatsisvili, June 2017, Braakman

Folding of the HIV-1 envelope glycoprotein in the ER

Nicholas McCaul, May 2017, Braakman


  Uncovering function of Grp94, the endoplasmic reticulum Hsp90

Abhinav Pandey, February 2016, Braakman

  Sources of artefacts in biomolecular NMR spectroscopy

Andrea Vavrinská, January 2016, Braakman and Trantirek


  HIV-1 envelope glycoprotein gp160 – biosynthesis, structure and function

Matthias Quandte, June 2014, Braakman

  Folding of influenza virus hemagglutinin in insect cells

Xin Li, April 2014, Braakman

  Folding of the LDL receptor dissected

Sabine Gremme, February 2014, Braakman


  Large disordered regions guard Wnt signalling

David-Paul Minde, November 2013, Braakman and Rüdiger


  Structural dynamics of the Hsp90 chaperone machine

Tatiana Didenko, May 2012, Braakman and Rüdiger


  Axin tumour suppressor function and dysfunction in the Wnt/β-catenin signalling pathway
Zeinab Anvarian, October 2011, Rüdiger
Protein scaffolding in the Wnt/β signalling regulation
Maria Noutsou, October 2011, Rüdiger
The Hsp90 chaperone in action: following the ATP cycle of a molecular machine

Elif Karagöz, April 2011, Braakman and Rüdiger


  Helping hands – Molecular chaperones for protein kinases

Sandra Kling, December 2010, Braakman and Rüdiger

Hsp90 molecular chaperone: The effect on breast cancer cell invasion and functional interactions with Aha1 co-chaperone

Jakub Urbański, September 2010, Braakman, Utrecht/Warsaw

  Folding defects and rescue mechanisms of DF508 CFTR

Hanneke Hoelen, June 2010, Braakman


  Grp94 – between ER resident chaperone and UPR regulator

Viorica Lastun, August 2009, Braakman


  The endoplasmic reticulum: a dynamic protein folding environment

Chantal Christis, May 2007, Braakman


  Initial characterization of folding, structure, and function of the new ER protein smERp1

Nicole Hafkemeijer, March 2006, Braakman


  Oxidative protein folding in the ER: the roles of PDI, Ero1a and ERp44

Jenny Smit, November 2005, Braakman

  Folding of two viral glycoproteins: Influenza Hemagglutinin and HIV-1 Envelope

Marije Liscaljet, May 2005, Braakman

  Folding of CFTR at the endoplasmic reticulum

Bertrand Kleizen, March 2005, Braakman


Claudia Maggioni, November 2003, Braakman
  Chaperones and peroxisomes

Wim de Jonge, October 2003, Braakman

  Versatility of the ER folding factory and the making & breaking of disulfide bonds

Eelco van Anken, October 2003, Braakman


  Folding of the LDL receptor in the endoplasmic reticulum

Annemieke Jansens, September 2002, Braakman


  Folding of the Human Immunodeficiency virus Envelope glycoprotein in the endoplasmic reticulum

Aafke Land, June 2001, Braakman