PhD theses




Unfolding IRE1α/β: How IRE1 accommodates stress at mucosal surfaces

Mariska Simpson, August 2023, Braakman, Lencer, and Grey


CFTR folding in health and disease

Tamara Hillenaar, April 2023, Braakman and van der Sluijs




Molecular chaperones in neurodegeneration

Margreet Koopman, April 2022, Rüdiger



Uncovering CFTR folding through patient mutations

Marcel van Willigen, September 2020, Braakman and van der Sluijs

Folding of CFTR transmembrane domains in the endoplasmic reticulum

Hiu Ying Yeoh, March 2020, Braakman and van der Sluijs



Control of Tau Aggregation by Molecular Chaperones

Luca Ferrari, June 2019, Rüdiger

The mechanism of action of molecular chaperones

Tania Morán Luengo, April 2019, Rüdiger

Unraveling the puzzle of CFTR domain folding and assembly

Marjolein Mijnders, February 2019, Braakman, van der Sluijs and Kleizen

Oxidative folding of influenza virus hemagglutinin subtypes

Doron Gollnast, January 2019, Braakman and van der Sluijs



Stories of a Diva – Interactions of the Hsp90 chaperone machinery with client proteins

Martina Rádli, March 2018, Rüdiger



CFTR folding and the molecular chaperone Hsp90

Daniel Mesquita da Fonseca, November 2017, Braakman, van der Sluijs and Kleizen

Role of CNPY5 in B cell activation and immunoglobulin production

Naomi Lodder, October 2017, Braakman and van der Sluijs

Re-evaluation of PDI function in mammalian cells

Anna Chatsisvili, June 2017, Braakman

Folding of the HIV-1 envelope glycoprotein in the ER

Nicholas McCaul, May 2017, Braakman



Uncovering function of Grp94, the endoplasmic reticulum Hsp90

Abhinav Pandey, February 2016, Braakman

Sources of artefacts in biomolecular NMR spectroscopy

Andrea Vavrinská, January 2016, Braakman and Trantirek



HIV-1 envelope glycoprotein gp160 – biosynthesis, structure and function

Matthias Quandte, June 2014, Braakman  

Folding of influenza virus hemagglutinin in insect cells

Xin Li, April 2014, Braakman  

Folding of the LDL receptor dissected

Sabine Gremme, February 2014, Braakman



Large disordered regions guard Wnt signalling

David-Paul Minde, November 2013, Rüdiger



Molecular mechanisms regulating exocytosis from post Golgi compartments

Emma Martínez Sánchez, July 2012, van der Sluijs

Structural dynamics of the Hsp90 chaperone machine 

Tatiana Didenko, May 2012, Rüdiger



Axin tumour suppressor function and dysfunction in the Wnt/β-catenin signalling pathway

Zeinab Anvarian, October 2011, Rüdiger

Protein scaffolding in the Wnt/β signalling regulation

Maria Noutsou, October 2011, Rüdiger

The Hsp90 chaperone in action: following the ATP cycle of a molecular machine

Elif Karagöz, April 2011, Rüdiger  

The role of munc13-4 in release of secretory lysosomes from hematopoietic cells

Edo Elstak, July 2012, van der Sluijs



Helping hands – Molecular chaperones for protein kinases

Sandra Kling, December 2010, Rüdiger

Hsp90 molecular chaperone: The effect on breast cancer cell invasion and functional interactions with Aha1 co-chaperone

Jakub Urbański, September 2010, Braakman, Utrecht/Warsaw  

Folding defects and rescue mechanisms of DF508 CFTR

Hanneke Hoelen, June 2010, Braakman



Grp94 – between ER resident chaperone and UPR regulator

Viorica Lastun, August 2009, Braakman



Mechanisms of secretory lysosome exocytosis in hematopoietic cells

Maaike Neeft, September 2008, van der Sluijs  

Defining functional interaction networks of rab GTPases using proteomics

Thijs van Vlijmen, Juni 2008, van der Sluijs



rab GTPases during mitosis

Claudia Fila, December 2007, van der Sluijs  

Molecular and functional characterization of BAIAP3 and munc13-4

Marnix Wieffer, September 2007, van der Sluijs  

The endoplasmic reticulum: a dynamic protein folding environment

Chantal Christis, May 2007, Braakman  

rab4 and its interacting proteins in endosome function

Ioana Popa, May 2007, van der Sluijs



Rabip4′ in protein sorting from endosomes

Viorica Ivan, Juni 2007, van der Sluijs  

Initial characterization of folding, structure, and function of the new ER protein smERp1

Nicole Hafkemeijer, March 2006, Braakman



Oxidative protein folding in the ER: the roles of PDI, Ero1a and ERp44

Jenny Smit, November 2005, Braakman  

Folding of two viral glycoproteins: Influenza Hemagglutinin and HIV-1 Envelope

Marije Liscaljet, May 2005, Braakman  

Folding of CFTR at the endoplasmic reticulum

Bertrand Kleizen, March 2005, Braakman



Recessive and dominant nephrogenic diabetes insipidus – novel molecular and cellular mechanisms

Paul JM Savelkoul, December 2004, van der Sluijs  

CD2-associated protein

Ari Ora, May 2004, van der Sluijs



Intra- and extracellular factors involved in the trafficking of the aquaporin-2 water channel

Bas van Balkom, December 2003, van der Sluijs

ER expansion and folding of viral glycoproteins

Claudia Maggioni, November 2003, Braakman  

Chaperones and peroxisomes

Wim de Jonge, October 2003, Braakman  

Versatility of the ER folding factory and the making & breaking of disulfide bonds

Eelco van Anken, October 2003, Braakman  

Synthesis and sorting of the aquaproin-2 water channel

Giel Hendriks, September 2003, van der Sluijs



Rab GTPases and their binding proteins in the regulation of endocytosis

Magdalena Deneka, November 2002, van der Sluijs  

Folding of the LDL receptor in the endoplasmic reticulum

Annemieke Jansens, September 2002, Braakman



Folding of the Human Immunodeficiency virus Envelope glycoprotein in the endoplasmic reticulum

Aafke Land, June 2001, Braakman

The role of the small GTPase rab4 in endosome function

Karin Mohrmann, Juni 2001, van der Sluijs  

A role for glycosphingolipids in protein sorting

Hein Sprong, May 2001, van der Sluijs