Reviews, Methods, Comments


Bross P, Gersting SW, McCaffrey K, Gremme S, Muntau A, Braakman I, Gregersen N. Protein Folding and misfolding: the role of cellular protein quality control systems in inherited disorders. The Online Metabolic and Molecular Bases of Inherited Disease. Valle D, Antonarakis S, Ballabio A, Beaudet A, Mitchell GA (Ed.) McGraw-Hill Medical (2020) Chapter 13.1, DOI: 10.1036/ommbid.308 Link

Schildknegt D, Lodder N, Pandey A, Egmond MR, Pena F, Braakman I, van der Sluijs P. Characterization of CNPY5 and its family members. Prot Sci. 2019 pro.3635 Link

Joshi U, Houwman JA, van der Sluijs P. Lysosomes nor mice move forward without Borcs7. Trends Cell Biol. 2018 28(10):761-763. Link

Feige MJ, Braakman I, Hendershot LM. Disulfide bonds in protein folding and stability. Oxidative folding of proteins: basic principles, cellular regulation and engineering. 2018 Chapter 1.1. Link

McCaffrey K, Braakman I. Protein quality control at the endoplasmic reticulum. Essays Biochem. 2016 60(2):227-235. Link

Ellgaard L, McCaul N, Chatsisvili A, Braakman I. Co- and Post-Translational Protein Folding in the ER. Traffic. 2016 17(6):615-38. Link

Heijnen H, and van der Sluijs P. Platelet secretory behavior: as diverse as the granules ……or not? J Thromb Hemost. 2015 13: 2141-51. Link

van der Sluijs P. Early endosomal compartments. Encyclopedia of Cell Biology. 2015 192-200. Link

Braakman I, Hebert DN. Protein folding in the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013 5(5):a013201. Link

van der Sluijs P, Zibouche M, van Kerkhof P. Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes. Frontiers Immunol. 2013 18: 359. Link

Tabak HF, Braakman I, van der Zand A. Peroxisome formation and maintenance are dependent on the endoplasmic reticulum. Annu Rev Biochem. 2013 82:723-44. Link

Braakman I, Bulleid NJ. Protein folding and modification in the mammalian endoplasmic reticulum. Annu Rev Biochem. 2011 80:71-99. Link

van der Sluijs P, Hoogenraad CC. New insights in endosomal dynamics and AMPA receptor trafficking. Semin Cell Dev Biol 2011 22: 499-505. Link

Balch WE, Braakman I, Frizzell R, Guggino W, Lukacs G, Penland C, Skach W, Sorscher E, Thomas P, Pollard H. The folding biology of cystic fibrosis: a consortium-based approach to disease. Protein misfolding diseases : current and emerging principles and therapies. 2010. Chapter 19. Link

Christis C, Lubsen NH, Braakman I. Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol. FEBS J. 2008 275(19):4700-27. Link

Tabak HF, van der Zand A, Braakman I. Peroxisomes: minted by the ER. Curr Opin Cell Biol. 2008 20(4):393-400. Link

Tabak HF, Hoepfner D, van der Zand A, Geuze HJ, Braakman I, Huynen MA. Formation of peroxisomes: present and past. Biochim Biophys Acta. 2006 1763(12):1647-54. Link

van der Zand A, Braakman I, Geuze HJ, Tabak HF. The return of the peroxisome. J Cell Sci. 2006 119(Pt 6):989-94. Link

De Jonge W, Tabak HF, Braakman I. Chaperone proteins and peroxisomal protein import. Top Curr Genet – Chaperones. 2006 Chapter 6:149-83. Link

van Anken E, Braakman I. Endoplasmic reticulum stress and the making of a professional secretory cell. Crit Rev Biochem Mol Biol. 2005 40(5):269-83. Link

van Anken E, Braakman I. Versatility of the endoplasmic reticulum protein folding factory. Crit Rev Biochem Mol Biol. 2005 40(4):191-228. Link

Maggioni C, Braakman I. Synthesis and quality control of viral membrane proteins. Curr Top Microbiol Immunol. 2005 285:175-98. Link

Gent J, Braakman I. Low-density lipoprotein receptor structure and folding. Cell Mol Life Sci. 2004 61(19-20):2461-70. Link

Kleizen B, Braakman I. Protein folding and quality control in the endoplasmic reticulum. Curr Opin Cell Biol. 2004 16(4):343-9. Link
Erratum in: Curr Opin Cell Biol. 2004 16(5):597. Link

Sitia R, Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature. 2003 426(6968):891-4. Link

Deneka M, Neeft M, van der Sluijs P. Regulation of membrane transport by rab GTPases. Crit Rev Biochem Mol Biol. 2003 38, 121-42. Link

Land A, Braakman I. Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum. Biochimie. 2001 83(8):783-90. Link

Sprong H, van der Sluijs P, van Meer G. How proteins move lipids and lipids move proteins. Nature Revs. Mol Cell Biol. 2001 2: 504-14. Link

Benham AM, Braakman I. Glycoprotein folding in the endoplasmic reticulum. Crit Rev Biochem Mol Biol. 2000 35(6):433-73. Link

Braakman I, van Anken E. Folding of viral envelope glycoproteins in the endoplasmic reticulum. Traffic. 2000 1(7):533-9. Link

Kleizen B, Braakman I, de Jonge HR. Regulated trafficking of the CFTR chloride channel. Eur J Cell Biol. 2000 79(8):544-56. Link

Distel B, Braakman I, Elgersma Y, Tabak HF. Transactions at the peroxisomal membrane. Subcellular Biochemistry – Fusion of biological membranes and related problems. 2000 Chapter 8:303-22. Link

Tabak HF, Braakman I, Distel B. Peroxisomes: simple in function but complex in maintenance. Trends Cell Biol. 1999 9(11):447-53. Link

van der Sluijs P, Gerez, L. Rab GTPases as regulators of transport through endosomes. Protoplasma 1999 210: 1-10. Link

van der Sluijs P. The small GTPase rab4 and membrane transport. GTPase controlled molecular machines. 1994 271-83.

Helenius A, Tatu U, Marquardt T, Braakman I. Protein Folding in the Endplasmic Reticulum. Cell Biology and Biotechnology. 1993 Chapter 10: 125-36. Link

Helenius A, Marquardt T, Braakman I. The endoplasmic reticulum as a protein-folding compartment. Trends Cell Biol. 1992 2(8):227-31. Link

van der Sluijs P, Meijer DKF. Limitations on the specificity of targeting asialoglycoprotein conjugates to the liver. Targeted diagnosis of liver diseases: cell surface receptors and directed agents. 1991 Chapter 11:235-64.


McCaul N, Yeoh H Y, van Zadelhoff G, Lodder N, Kleizen B, Braakman I. Analysis of protein folding, transport, and degradation in living cells by radioactive pulse chase. JoVE. 2019 144. Link

Braakman I, Lamriben L, van Zadelhoff G, Hebert DN. Analysis of disulfide bond formation. Curr Protoc Protein Sci. 2017 90:14.1.1-14.1.21. Link

Ivan V, van der Sluijs P. Methods for Analysis of AP-3/Rabip’ in Regulation of Lysosome Distribution. Methods Mol Biol. 2015 1298:245-58. Link
Erratum Link

Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA. CFTR Folding Consortium: methods available for studies of CFTR folding and correction. Methods Mol Biol. 2011 742:335-53. Link

van der Sluijs P, Neeft M, van Vlijmen T, Elstak E, Wieffer M. Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells. Meth Enzymol. 2008 438: 185-201. Link

Popa I, Deneka M, van der Sluijs P. Expression and properties of the Rab4, Rabaptin-5alpha, AP-1 complex in endosomal recycling. Meth Enzymol. 2005 403, 526-40. Link

Liscaljet IM, Kleizen B, Braakman I. Studying protein folding in vivo. Protein Folding Handbook. 2005 Part II, Volume 1, Chapter 3: 73-104. Link

Jansens A, Braakman I. Pulse-chase labeling techniques for the analysis of protein maturation and degradation. Methods Mol Biol. 2003 232:133-45. Link

Braakman I, Hebert DN. Analysis of disulfide bond formation. Curr Protoc Protein Sci. 2001 Chapter 14:Unit14.1. Link

van der Sluijs P, Mohrmann K, Deneka M, Jongeneelen M. Expression and properties of rab4 and its effector rabaptin-4 in endocytic recycling. Meth Enzymol. 2000 329: 111-9. Link

Sprong H, van Meer G, van der Sluijs P. Analysis of galactolipids and UDP-galactose: ceramide galactosyltransferase. Meth Enzymol. 1999 311: 59-73. Link


Armengaud J, Delaunay‐Moisan A, Thuret JY, van Anken E, Acosta‐Alvear D, Aragón T, Arias C, Blondel M, Braakman I, Collet JF, Courcol R, Danchin A, Deleuze J‐F, Lavigne J‐P, Lucas S, Michiels T, Moore ER, Nixon‐Abell J, Rossello‐Mora R, Shi Z, Siccardi AG, Sitia R, Tillett D, Timmis KN, Toledano MB, van der Sluijs P and Vicenzi E. The Importance Of Naturally Attenuated Sars‐Cov‐2 In The Fight Against Covid‐19. Environ. Microbiol. 2020 Link

Kleizen B, Braakman I. Cell biology. A sweet send-off. Science. 2013 340(6135):930-1. Link

Braakman I. Entering a new era with Ero. Nat Rev Mol Cell Biol. 2009 10(8):503. Link

Braakman I, Otsu M. Biochemistry. Cargo load reduction. Science. 2008 321(5888):499-500. Link

Deneka M, van der Sluijs P. ‘Rab’ing up endosomal membrane transport. Nature Cell Biol. 2002 4, E32-5. Link

Braakman I. A novel lectin in the secretory pathway. An elegant mechanism for glycoprotein elimination. EMBO Rep. 2001 2(8):666-8. Link