Recent Publications

Recent publications at CPC

Bross P, Gersting SW, McCaffrey K, Gremme S, Muntau A, Braakman I, Gregersen N. Protein Folding and misfolding: the role of cellular protein quality control systems in inherited disorders. The Online Metabolic and Molecular Bases of Inherited Disease. Valle D, Antonarakis S, Ballabio A, Beaudet A, Mitchell GA (Ed.) McGraw-Hill Medical (2020) Chapter 13.1, DOI: 10.1036/ommbid.308 Link

Ferrari L, Stucchi R, Konstantoulea K, van der Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun. 2020 11:571 Link

Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R & Hiller S. Regulation of α-synuclein by chaperones in mammalian cells. Nature 2020 577:127-32 Link

Kleizen B, Hunt JF, Callebaut I, Hwang T-C, Sermet-Gaudelus I, Hafkemeyer S, Sheppard DN. CFTR: New insights into structure and function and implications for modulation by small molecules. J Cyst Fibros. 2019. Link

Ferrari L, Rüdiger SGD. (2019) Hsp90 Chaperone in Disease. In: Asea A., Kaur P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. Link

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman IV JL, Ignatova Z, Sorscher EJ. Slowing ribosome velocity restores folding and function of mutant CFTR. J Clin Invest. 2019 129(12) Link

Schildknegt D, Lodder N, Pandey A, Egmond MR, Pena F, Braakman I, van der Sluijs P. Characterization of CNPY5 and its family members. Prot Sci. 2019 pro.3635 Link

Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes G-J, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A. MAP7 family proteins regulate kinesin-1 recruitment and activation. J Cell Biol. 2019 218(4):1298-1318. Link

McCaul N, Yeoh H Y, van Zadelhoff G, Lodder N, Kleizen B, Braakman I. Analysis of protein folding, transport, and degradation in living cells by radioactive pulse chase. JoVE. 2019 144. Link (Video article, see also Methods)

Morán Luengo T, Mayer MP, Rüdiger SGD. The Hsp70-Hsp90 chaperone cascade in protein folding. Trends Cell Biol. 2019 29(2):164-177. Link

van Willigen M, Vonk AM, Yeoh HY, Kruisselbrink E, Kleizen B, van der Ent CK, Egmond MR, de Jonge HR, Braakman I, Beekman JM, van der Sluijs P. Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants. Life Sci Alliance. 2019 2(1): Link