Recent Publications

Recent publications at CPC

Kleizen B, Hunt JF, Callebaut I, Hwang T-C, Sermet-Gaudelus I, Hafkemeyer S, Sheppard DN. CFTR: New insights into structure and function and implications for modulation by small molecules. J Cyst Fibros. 2019. Link

Ferrari L, Rüdiger SGD. (2019) Hsp90 Chaperone in Disease. In: Asea A., Kaur P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. Link

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman IV JL, Ignatova Z, Sorscher EJ. Slowing ribosome velocity restores folding and function of mutant CFTR. J Clin Invest. 2019 129(12) Link

Schildknegt D, Lodder N, Pandey A, Egmond MR, Pena F, Braakman I, van der Sluijs P. Characterization of CNPY5 and its family members. Prot Sci. 2019 pro.3635 Link

Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes G-J, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A. MAP7 family proteins regulate kinesin-1 recruitment and activation. J Cell Biol. 2019 218(4):1298-1318. Link

McCaul N, Yeoh H Y, van Zadelhoff G, Lodder N, Kleizen B, Braakman I. Analysis of protein folding, transport, and degradation in living cells by radioactive pulse chase. JoVE. 2019 144. Link (Video article, see also Methods)

Morán Luengo T, Mayer MP, Rüdiger SGD. The Hsp70-Hsp90 chaperone cascade in protein folding. Trends Cell Biol. 2019 29(2):164-177. Link

van Willigen M, Vonk AM, Yeoh HY, Kruisselbrink E, Kleizen B, van der Ent CK, Egmond MR, de Jonge HR, Braakman I, Beekman JM, van der Sluijs P. Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants. Life Sci Alliance. 2019 2(1): Link

Ferrari L, Rüdiger SGD. Recombinant production and purification of the human protein Tau. Protein Eng Des Sel 2018 31(12):447-455. Link

Joshi U, Houwman JA, van der Sluijs P. Lysosomes nor mice move forward without Borcs7. Trends Cell Biol. 2018 28(10):761-763. Link

Nag S, Rani S, Mahanty S, Bissig C, Arora P, Azevedo C, Saiardi A, van der Sluijs P, Delevoye C, van Niel G, Raposo G, Setty SRG. Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles. J Cell Sci. 2018 131(18). Link

Radli M, Rüdiger SG. Dancing with the diva: Hsp90-client interactions J Mol Biol. 2018 14:430 Link

Feige MJ, Braakman I, Hendershot LM. Disulfide bonds in protein folding and stability. Oxidative folding of proteins: basic principles, cellular regulation and engineering. 2018 Chapter 1.1. Link

Mall MA, Hwang TC, Braakman I. Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman’s summary. J Cyst Fibros. 2018 17(2S):S1-S4. Link

Morán Luengo T, Kityk R, Mayer MP, Rüdiger SGD. Hsp90 breaks the deadlock of the Hsp70 chaperone system. Mol Cell. 2018 70:545-552 (cover story). Link

Bin NR, Ke Ma, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier P, Gaisano H, Sugita S. C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells. J. Immunol. 2018 20:700-13doi: 10.4049/jimmunol.1800426. Link

Dhekne HS, Pylypenko O, Overeem AW, Ferreira RJ, van der Velde KJ, Rings EHHM, Posovszky C, Swertz MA, van der Sluijs P, Houdusse A, van IJzendoorn SCD. MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update. Hum Mutat. 2018 39(3):333-44. doi: 10.1002/humu.23386.

Jonker CTH, Galmes R, Veenendaal T, ten Brink C, van de Welle REN, Liv N, de Rooij J, Peden A, van der Sluijs P, Mardant C, Klumperman J. Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions, Nature Comm. 2018 9, doi:10.1038/s41467-018-03226-8. Link