Scientific Staff
Adabella van der Zand
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Postdoctoral researchers
PhD candidates
Laura Tadé
+31 30 253 3752
l.tade@uu.nl
Office: O.709
I want to know whether CFTR is only active at the cell surface or also in other cell compartments and when/where it acquires the structure that allows its function.
I focus on the role of molecular chaperones – such as Hsp70 and Hsp90 – and their role in the aggregation process of Tau, a protein involved in Alzheimer’s Disease.
My research focuses on how Hsp90 selects its client proteins, as known Hsp90 binding partners recruit from various protein families and do not share functional or structural similarities.
The aim of my research is to determine for each CFTR2 disease-causing mutant to which available (pre)clinical drugs they respond at the CFTR protein level.
My project investigates how CFTR transmembrane domains assemble, and see how chaperones help with the assembly of these transmembrane domains with each other and nucleotide binding domains.
Technicians
I am interested in a set of small endoplasmic reticulum localized chaperones, called the canopy family and their role in proteins folding, B cell differentiation and antibody secretion.
I develop/modify analysis techniques to study protein folding of model oxidative proteins and folding factors, in vivo and in vitro by short and long radioactive metabolic labelling.
My research is about comparing genetic disease causing protein mutants to their wildtype variant by limited proteolysis and see if chaperones are able to stabilize these mutants.
Students
Guests
Maarten Egmond