People

Tel: +31 30 253 ….
Email: ….@uu.nl

Scientific Staff

Ineke Braakman
Tel: 2759
Email: i.braakman
Office: O.705
Full professor


Stefan Rüdiger
Tel: 3394
Email: s.g.d.rudiger
Office: O.704
Associate professor


Peter van der Sluijs
Tel: 2490
Email: p.vandersluijs1
Office: O.702
Associate professor


Bertrand Kleizen
Tel: 2490
Email: b.kleizen
Office: O.702
Assistant professor


Adabella van der Zand

Email: a.vanderzand


Support

Marjolein Smithuis
Tel: 2184
Email: science.folding
Office: O.703
Secretary


Joseline Houwman
Tel: 3898
Email: cpc
Office: O.703
Scientific assistant

Postdoctoral researchers

Priyanka Sahasrabudhe
Tel: 3354
Email: p.j.sahasrabudhe
Office: O.701

I aim to discover the mode of action of novel corrector drugs developed to rescue cell surface function of CFTR and gain more insight into how mutations and cellular factors affect protein folding.


Dragana Vidocic
Tel: 3601
Email: d.vidovic
Office: O.706


I want to identify molecular chaperones that are involved in folding of CFTR’s NBD1 domain, the location of the most common disease-causing mutation (F508del), and how they assist with NBD1 folding.

Urjita Joshi
Tel: 3841
Email: u.r.joshi
Office: O.710

My project aims to identify the key players in the transport and recycling of CFTR protein at the plasma membrane by employing biochemical and fluorescence (immune) imaging techniques.

PhD candidates

Ying Yeoh
Tel: 3354
Email: h.y.yeoh
Office: O.701

My aim is to identify intramembrane interaction partners of CFTR and how these are involved in chaperoning and quality control of folding of the transmembrane region of CFTR.


Marjolein Mijnders
Tel: 3601
Email: m.mijnders
Office: O.706


I study the folding and misfolding of CFTR and the effects of potential therapeutics on its folding/misfolding to aid in the development of transformative therapies.


Laura Tadé
Tel: 3752
Email: l.tade
Office: O.709


I want to know whether CFTR is only active at the cell surface or also in other cell compartments and when/where it acquires the structure that allows its function.


Marcel van Willigen
Tel: 4105
Email: m.vanwilligen
Office: O.707


My research focuses on investigating CFTR folding using Cystic Fibrosis patient mutations, providing insights into how wild-type protein folds and how the respective patient mutants misfold.


Luca Ferrari
Tel: 3841
Email: l.ferarri
Office: O.710

I focus on aggregation-prone proteins linked to neurodegeneration. I am especially interested in understanding how Hsp90 can modulate Tau aggregation and its associated interactome.


Tania Morán Luengo
Tel: 3601
Email: t.moranluengo
Office: O.706

My research focuses on the interplay between the chaperones Hsp70 and Hsp90, with emphasis on the purpose of Hsp90 and the function of the Hsp70/Hsp90 folding cascade.


Margreet Koopman
Tel: 4105
Email: m.b.koopman
Office: O.707

I focus on the role of molecular chaperones – such as Hsp70 and Hsp90 – and their role in the aggregation process of Tau, a protein involved in Alzheimer’s Disease.


Magdalena Wawrzyniuk
Tel: 2490
Email: m.wawrzynuik
Office: O.702

My research focuses on how Hsp90 selects its client proteins, as known Hsp90 binding partners recruit from various protein families and do not share functional or structural similarities.

Technicians

Floor Peters
Tel: 3601
Email: f.m.a.peters
Office: O.706

I work on elucidating the mode of action of compounds that affect CFTR folding, to understand mechanisms of these compounds and their potential benefits for Cystic Fibrosis patients.


Danny Schildknegt
Tel: 3841
Email: d.schildknegt
Office: O.710

I am interested in a set of small endoplasmic reticulum localized chaperones, called the canopy family and their role in proteins folding, B cell differentiation and antibody secretion.


Guus van Zadelhoff
Tel: 3752
Email: g.vanzadelhoff
Office: O.709

I develop/modify analysis techniques to study protein folding of model oxidative proteins and folding factors, in vivo and in vitro by short and long radioactive metabolic labelling.

Students

Erik Slot


Sem Halters


Gerarda van de Kamp

Guests

Maarten Egmond

Email: m.r.egmond