Braakman & van der Sluijs group

Eduardo de Mattos
+31 30 253 ….
e.demattos@uu.nl
Office: O.707

I investigate how folding intermediates of CFTR and their interaction with cellular protein quality control mechanisms modulates CFTR structure and function.

Tamara Hillenaar
+31 30 253 ….
m.j.h.hillenaar@uu.nl
Office: O.706

The aim of my research is to determine for each CFTR2 disease-causing mutant to which available (pre)clinical drugs they respond at the CFTR protein level.

Jisu Im
+31 30 253 ….
j.im@uu.nl
Office: O.709

My project investigates how CFTR transmembrane domains assemble, and see how chaperones help with the assembly of these transmembrane domains with each other and nucleotide binding domains.

Laura Tadé
+31 30 253 ….
l.tade@uu.nl
Office: DDW

I want to know whether CFTR is only active at the cell surface or also in other cell compartments and when/where it acquires the structure that allows its function.

Guus van Zadelhoff
+31 30 253 3752
g.vanzadelhoff@uu.nl
Office: O.709

I develop/modify analysis techniques to study protein folding of model oxidative proteins and folding factors, in vivo and in vitro by short and long radioactive metabolic labelling.

Senna Hiensch
+31 30 253 3841
s.hiensch@uu.nl
Office: O.706

My research is about comparing genetic disease causing protein mutants to their wildtype variant by limited proteolysis and see if chaperones are able to stabilize these mutants.

Danny Schildknegt
+31 30 253 3841
d.schildknegt@uu.nl
Office: O.710

I am interested in a set of small endoplasmic reticulum localized chaperones, called the canopy family and their role in proteins folding, B cell differentiation and antibody secretion.