Braakman & van der Sluijs group

Scientific Staff

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Project manager

Joseline Houwman
+31 30 253 3898
j.a.houwman@uu.nl
Office: O.703

 

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Postdoctoral researchers

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PhD candidates

Laura Tadé
+31 30 253 . . . .
l.tade@uu.nl
Office: DDW building

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I want to know whether CFTR is only active at the cell surface or also in other cell compartments and when/where it acquires the structure that allows its function.

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The aim of my research is to determine for each CFTR2 disease-causing mutant to which available (pre)clinical drugs they respond at the CFTR protein level.

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My project investigates how CFTR transmembrane domains assemble, and see how chaperones help with the assembly of these transmembrane domains with each other and nucleotide binding domains.

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I am interested in a set of small endoplasmic reticulum localized chaperones, called the canopy family and their role in proteins folding, B cell differentiation and antibody secretion.

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I develop/modify analysis techniques to study protein folding of model oxidative proteins and folding factors, in vivo and in vitro by short and long radioactive metabolic labelling.

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My research is about comparing genetic disease causing protein mutants to their wildtype variant by limited proteolysis and see if chaperones are able to stabilize these mutants.

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Students

 

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Guests

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