Scientific Staff
Adabella van der Zand
Project manager
Joseline Houwman
+31 30 253 3898
j.a.houwman@uu.nl
Office: O.703
Postdoctoral researchers
PhD candidates
Laura Tadé
+31 30 253 . . . .
l.tade@uu.nl
Office: DDW building
I want to know whether CFTR is only active at the cell surface or also in other cell compartments and when/where it acquires the structure that allows its function.
The aim of my research is to determine for each CFTR2 disease-causing mutant to which available (pre)clinical drugs they respond at the CFTR protein level.
My project investigates how CFTR transmembrane domains assemble, and see how chaperones help with the assembly of these transmembrane domains with each other and nucleotide binding domains.
Technicians
I am interested in a set of small endoplasmic reticulum localized chaperones, called the canopy family and their role in proteins folding, B cell differentiation and antibody secretion.
I develop/modify analysis techniques to study protein folding of model oxidative proteins and folding factors, in vivo and in vitro by short and long radioactive metabolic labelling.
My research is about comparing genetic disease causing protein mutants to their wildtype variant by limited proteolysis and see if chaperones are able to stabilize these mutants.
My project aims to investigate the correlation between translation rate and CFTR folding.
Students
Guests
Maarten Egmond