Recent Publications

Recent publications at CPC

McCaul ND, Quandte M, Bontjer I, van Zadelhoff G, Land A, Sanders RW and Braakman I, 2021. Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint. Cell Rep. 2021 36:9, 109646 Link

Dekker FA and Rüdiger SGD. The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease. Front. Mol. Biosci. 2021 8: 697913 Link

Aragonès Pedrola J, Rüdiger SGD. Double J-domain piloting of an Hsp70 substrate. J. Biol. Chem. 2021 100717 Link

Sabusap CM, Joshi D, Simhaev L, Oliver KE, Senderowitz H, van Willigen M, Braakman I, Rab A, Sorscher EJ, Hong JS. The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue. J. Biol. Chem. 2021 100598 Link

Kleizen B, van Willigen M, Mijnders M, Peters FM, Grudniewska MK, Hillenaar TM, Thomas AS, Kooijman L, Peters KW, Frizzell R, van der Sluijs P, Braakman I. Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain. J. Mol. Biol. 2021 13:166955 Link

Bhattacharya K, Weidenauer L, Luengo TM, Pieters EC, Echeverría PC, Bernasconi L, Wider D, Sadian Y, Koopman MB, Villemin M, Bauer C, Rüdiger SGD, Quadroni M, Picard D. The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nat. Comm. 2020 11:1-21 Link

Rüdiger SGD, Koopman MB. Alzheimer cells on their way to derailment show selective changes in protein quality control network. Front. Mol. Biosci. 2020 fmolb.2020.00214 Link

Koopman MB, Rüdiger SGD. Behind closed gates–chaperones and charged residues determine protein fate. EMBO J. 2020 e104939 Link

Armengaud J, Delaunay‐Moisan A, Thuret JY, van Anken E, Acosta‐Alvear D, Aragón T, Arias C, Blondel M, Braakman I, Collet JF, Courcol R, Danchin A, Deleuze J‐F, Lavigne J‐P, Lucas S, Michiels T, Moore ER, Nixon‐Abell J, Rossello‐Mora R, Shi Z, Siccardi AG, Sitia R, Tillett D, Timmis KN, Toledano MB, van der Sluijs P and Vicenzi E. The Importance Of Naturally Attenuated Sars‐Cov‐2 In The Fight Against Covid‐19. Environ. Microbiol. 2020 Link

Weickert S, Wawrzyniuk M, John LH, Rüdiger SGD, Drescher M. The mechanism of Hsp90-induced oligomerizaton of Tau. Science Adv. 2020 11:eaax6999 Link

Bross P, Gersting SW, McCaffrey K, Gremme S, Muntau A, Braakman I, Gregersen N. Protein Folding and misfolding: the role of cellular protein quality control systems in inherited disorders. The Online Metabolic and Molecular Bases of Inherited Disease. Valle D, Antonarakis S, Ballabio A, Beaudet A, Mitchell GA (Ed.) McGraw-Hill Medical 2020 Chapter 13.1, DOI: 10.1036/ommbid.308 Link

Ferrari L, Stucchi R, Konstantoulea K, van der Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun. 2020 11:571 Link

Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R & Hiller S. Regulation of α-synuclein by chaperones in mammalian cells. Nature 2020 577:127-32 Link