Recent publications at CPC
Jarosińska OD, Rüdiger SGD. Molecular Strategies to Target Protein Aggregation in Huntington’s Disease. Front. Mol. Biosci. 2021 8:1068 Link
Lashley T, Tossounian MA, Heaven NC, Wallworth S, Peak-Chew S, Bradshaw A, Cooper JM, de Silva R, Srai SK, Malanchuk O, Filonenko V, Koopman MB, Rüdiger SGD, Skehel M, Gout I. Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A. Front. Cell. Neurosci. 2021 15:411 Link
McCaul ND, Quandte M, Bontjer I, van Zadelhoff G, Land A, Crooks ET, Binley JM, Sanders RW Braakman I. Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint. Cell Rep. 2021 36:9, 109646 Link
Dekker FA and Rüdiger SGD. The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease. Front. Mol. Biosci. 2021 8: 697913 Link
Aragonès Pedrola J, Rüdiger SGD. Double J-domain piloting of an Hsp70 substrate. J. Biol. Chem. 2021 100717 Link
Sabusap CM, Joshi D, Simhaev L, Oliver KE, Senderowitz H, van Willigen M, Braakman I, Rab A, Sorscher EJ, Hong JS. The CFTR P67L variant reveals a key role fo’nr N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue. J. Biol. Chem. 2021 100598 Link
Kleizen B, van Willigen M, Mijnders M, Peters FM, Grudniewska MK, Hillenaar TM, Thomas AS, Kooijman L, Peters KW, Frizzell R, van der Sluijs P, Braakman I. Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain. J. Mol. Biol. 2021 13:166955 Link
Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O’Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Clinical and molecular characterization of the R751L-CFTR mutation. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2021 320(2):L288-L300 Link
Bhattacharya K, Weidenauer L, Luengo TM, Pieters EC, Echeverría PC, Bernasconi L, Wider D, Sadian Y, Koopman MB, Villemin M, Bauer C, Rüdiger SGD, Quadroni M, Picard D. The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nat. Comm. 2020 11:1-21 Link
Rüdiger SGD, Koopman MB. Alzheimer cells on their way to derailment show selective changes in protein quality control network. Front. Mol. Biosci. 2020 fmolb.2020.00214 Link
Koopman MB, Rüdiger SGD. Behind closed gates–chaperones and charged residues determine protein fate. EMBO J. 2020 e104939 Link
Armengaud J, Delaunay‐Moisan A, Thuret JY, van Anken E, Acosta‐Alvear D, Aragón T, Arias C, Blondel M, Braakman I, Collet JF, Courcol R, Danchin A, Deleuze J‐F, Lavigne J‐P, Lucas S, Michiels T, Moore ER, Nixon‐Abell J, Rossello‐Mora R, Shi Z, Siccardi AG, Sitia R, Tillett D, Timmis KN, Toledano MB, van der Sluijs P and Vicenzi E. The Importance Of Naturally Attenuated Sars‐Cov‐2 In The Fight Against Covid‐19. Environ. Microbiol. 2020 Link
Weickert S, Wawrzyniuk M, John LH, Rüdiger SGD, Drescher M. The mechanism of Hsp90-induced oligomerizaton of Tau. Science Adv. 2020 11:eaax6999 Link
Bross P, Gersting SW, McCaffrey K, Gremme S, Muntau A, Braakman I, Gregersen N. Protein Folding and misfolding: the role of cellular protein quality control systems in inherited disorders. The Online Metabolic and Molecular Bases of Inherited Disease. Valle D, Antonarakis S, Ballabio A, Beaudet A, Mitchell GA (Ed.) McGraw-Hill Medical 2020 Chapter 13.1, DOI: 10.1036/ommbid.308 Link
Ferrari L, Stucchi R, Konstantoulea K, van der Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun. 2020 11:571 Link
Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R & Hiller S. Regulation of α-synuclein by chaperones in mammalian cells. Nature 2020 577:127-32 Link