Rüdiger Lab – Publications

1   Minde DP, Radli M, Forneris F, Maurice MM#, Rüdiger SGD#. Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling  against point mutations. PLoS One. 2013 Oct 9;8(10):e77257. (# = corresponding author)

2   Xue B, Romero PR, Noutsou M, Maurice MM, Rüdiger SGD, William AM Jr, Mizianty MJ, Kurgan L, Uversky VN, Dunker AK. Stochastic machines as a colocalization mechanism for scaffold protein function. FEBS Lett. 2013 Jun 5;587(11):1587-91.

3   Minde DP, Maurice MM#, Rüdiger SGD#. Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. PLoS One. 2012;7(10):e46147. (# = corresponding author)

4   Suijkerbuijk SJ, van Dam TJ, Karagöz GE, von Castelmur E, Hubner NC, Duarte AM, Vleugel M, Perrakis A, Rüdiger SGD, Snel B, Kops GJ. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell. 2012 Jun 12;22(6):1321-9.

5   Li Y, Karagöz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K#, Rüdiger SGD#, Sun D#. Sulforaphane inhibits pancreatic cancer  through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 2012 Dec;23(12):1617-26. (# = corresponding author)

6   Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SGD, Schwamborn K, Schambony A, Maurice MM. Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with  a discontinuous motif in Frizzled. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20.

7   Didenko T, Duarte AM, Karagöz GE, Rüdiger SGD#. Hsp90 structure and function studied by NMR spectroscopy. Biochim Biophys Acta. 2012 Mar;1823(3):636-47. (# = corresponding author)

8   Minde DP, Anvarian Z, Rüdiger SGD#, Maurice MM#. Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? Mol Cancer. 2011 Aug 22;10:101. (# = corresponding author)

9   Karagöz GE, Sinnige T, Hsieh O, Rüdiger SGD#. Expressed protein ligation for a large dimeric protein. Protein Eng Des Sel. 2011 Jun;24(6):495-501. (# = corresponding author)

10 Katz C, Levy-Beladev L, Rotem-Bamberger S, Rito T, Rüdiger SGD, Friedler A. Studying protein-protein interactions using peptide arrays. Chem Soc Rev. 2011 May;40(5):2131-45.

11 Karagöz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJR, Boelens R, Rüdiger SGD#. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):580-5. (# = corresponding author)

12 Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I,  Oikonomou C, Friedler A, Boelens R, Rüdiger SGD#, Maurice MM#. Critical scaffolding  regions of the tumor suppressor Axin1 are natively unfolded. J Mol Biol. 2011 Jan 21;405(3):773-86. (# = corresponding author)

13 Didenko T, Boelens R, Rüdiger SGD#. 3D DOSY-TROSY to determine the translational diffusion coefficient of large protein complexes. Protein Eng Des Sel. 2011 Jan;24(1-2):99-103. (# = corresponding author)

14 Sinnige T, Karagöz GE, Rüdiger SGD#. Protein Folding and Chaperones. Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester (2010). (# = corresponding author)

15 Tsaytler PA, Krijgsveld J, Goerdayal SS, Rüdiger S, Egmond MR. Novel Hsp90 partners discovered using complementary proteomic approaches. Cell Stress Chaperones. 2009 Nov;14(6):629-38.

16 Rotem S, Katz C, Benyamini H, Lebendiker M, Veprintsev D, Rüdiger S, Danieli T, Friedler A. The structure and interactions of the proline-rich domain of ASPP2. J Biol Chem. 2008 Jul 4;283(27):18990-9.

17 Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A. Molecular basis  of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12277-82.

18 Rodriguez F, Arséne-Ploetze F, Rist W, Rüdiger S, Schneider-Mergener J, Mayer  MP, Bukau B. Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones. Mol Cell. 2008 Nov 7;32(3):347-58.

19 Mayer S, Rüdiger S, Ang HC, Joerger AC, Fersht AR. Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. J Mol Biol. 2007 Sep 7;372(1):268-76.

20 Vega CA, Kurt N, Chen Z, Rüdiger S, Cavagnero S. Binding specificity of an alpha-helical protein sequence to a full-length Hsp70 chaperone and its minimal substrate-binding domain. Biochemistry. 2006 Nov 21;45(46):13835-46.

21 Yu GW, Rüdiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1227-32.

22 Friedler A, DeDecker BS, Freund SMV, Blair C, Rüdiger S, Fersht AR. Structural  distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for “mutant conformation“. J Mol Biol. 2004 Feb 6;336(1):187-96.

23 Vandenbroeck K, Alloza I, Brehmer D, Billiau A, Proost P, McFerran N, Rüdiger S, Walker B. The conserved helix C region in the superfamily of interferon-gamma  /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK. J Biol Chem. 2002 Jul 12;277(28):25668-76.

24 Rüdiger S, Freund SMV, Veprintsev DB, Fersht AR. CRINEPT-TROSY NMR reveals p53  core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci  U S A. 2002 Aug 20;99(17):11085-90.

25 Hansson LO, Friedler A, Freund S, Rüdiger S, Fersht AR. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9.

26 Friedler A, Hansson LO, Veprintsev DB, Freund SMV, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S, Fersht AR. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U  S A. 2002 Jan 22;99(2):937-42.

27 Patzelt H, Rüdiger S, Brehmer D, Kramer G, Vorderwülbecke S, Schaffitzel E, Waitz A, Hesterkamp T, Dong L, Schneider-Mergener J, Bukau B, Deuerling E. Binding specificity of Escherichia coli trigger factor. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14244-9.

28 Schaffitzel E, Rüdiger S, Bukau B, Deuerling E. Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins. Biol Chem. 2001 Aug;382(8):1235-43.

29 Brehmer D, Rüdiger S, Gässler CS, Klostermeier D, Packschies L, Reinstein J, Mayer MP, Bukau B. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nat Struct Biol. 2001 May;8(5):427-32.

30 Rüdiger S, Schneider-Mergener J, Bukau B. Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone.  EMBO J. 2001 Mar 1;20(5):1042-50.

31 Rüdiger S, Mayer MP, Schneider-Mergener J, Bukau B. Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch. J Mol Biol. 2000 Dec 1;304(3):245-51.

32 Mayer MP, Rüdiger S, Bukau B. Molecular basis for interactions of the DnaK chaperone with substrates. Biol Chem. 2000 Sep-Oct;381(9-10):877-85. Review.

33 Mayer MP, Schröder H, Rüdiger S, Paal K, Laufen T, Bukau B. Multistep mechanism of substrate binding determines chaperone activity of Hsp70. Nat Struct Biol. 2000 Jul;7(7):586-93.

34 Mogk A, Tomoyasu T, Goloubinoff P, Rüdiger S, Röder D, Langen H, Bukau B. Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB. EMBO J. 1999 Dec 15;18(24):6934-49.

35 Knoblauch NT, Rüdiger S, Schönfeld HJ, Driessen AJ, Schneider-Mergener J, Bukau B. Substrate specificity of the SecB chaperone. J Biol Chem. 1999 Nov 26;274(48):34219-25.

36 Brix J, Rüdiger S, Bukau B, Schneider-Mergener J, Pfanner N. Distribution of  binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70  in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem. 1999 Jun 4;274(23):16522-30.

37 Rüdiger S, Buchberger A, Bukau B. Interaction of Hsp70 chaperones with substrates. Nat Struct Biol. 1997 May;4(5):342-9. Review.

38 Rüdiger S, Germeroth L, Schneider-Mergener J, Bukau B. Substrate specificity  of the DnaK chaperone determined by screening cellulose-bound peptide libraries.  EMBO J. 1997 Apr 1;16(7):1501-7.

39 McCarty JS, Rüdiger S, Schönfeld HJ, Schneider-Mergener J, Nakahigashi K, Yura T, Bukau B. Regulatory region C of the E. coli heat shock transcription factor, sigma32, constitutes a DnaK binding site and is conserved among eubacteria. J Mol Biol. 1996 Mar 15;256(5):829-37.

40 Gamer J, Multhaup G, Tomoyasu T, McCarty JS, Rüdiger S, Schönfeld HJ, Schirra C, Bujard H, Bukau B. A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J. 1996 Feb 1;15(3):607-17.

41 Herdegen T, Rüdiger S, Mayer B, Bravo R, Zimmermann M. Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw. Brain Res Mol Brain Res. 1994 Mar;22(1-4):245-58.