van der Sluijs group

2018

Bin NR, Ke Ma, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier P, Gaisano H, Sugita S. Munc13-4 is a major Ca2+ sensor for cytotoxic granule exocytosis in NK cells. J. Immunol. 2018 20:700-13doi: 10.4049/jimmunol.1800426. Link

Dhekne HS, Pylypenko O, Overeem AW, Ferreira RJ, van der Velde KJ, Rings EHHM, Posovszky C, Swertz MA, van der Sluijs P, Houdusse A, van IJzendoorn SCD. MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update. Hum Mutat. 2018 39(3):333-44. doi: 10.1002/humu.23386. Link

Jonker CTH, Galmes R, Veenendaal T, ten Brink C, van de Welle REN, Liv N, de Rooij J, Peden A, van der Sluijs P, Mardant C, Klumperman J. Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions, Nature Comm. 2018 9, doi:10.1038/s41467-018-03226-8. Link

2017

Chehab T, Criado Santos N, Holthenrich A, Koerdt SN, Disse J, Schuberth C, Reza Nazmi A., Neeft M, Koch H, Man KNM, Wojcik SM, Martin TFJ, van der Sluijs P, Brose N, Gerke V. A novel Munc13-4 / S100A10 / Annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells. Mol. Biol. Cell. 2017 28:1688-1700. Link

2015

Ivan V, van der Sluijs P. Methods for Analysis of AP-3/Rabip’ in Regulation of Lysosome Distribution. Methods Mol Biol. 2015 1298:245-58. Link
Erratum Link

Heijnen H, and van der Sluijs P. Platelet secretory behavior: as diverse as the granules ……or not? J. Thromb. Hemost. 2015 13: 2141-51. Link

Galmes R, ten Brink C, Oorschot V, Veenendaal T, Jonker C, van der Sluijs P, Klumperman J. Vps33B is required for delivery of endocytosed cargo to lysosomes. Traffic 2015 16: 1288- 1305. Link

van der Sluijs P. Early endosomal compartments. Encyclopedia of Cell Biology. 2015 192-200. Link

2014

Hagemeijer MC, Monastyrska I, Griffith J, van der Sluijs P, Voortman J, van Bergen en Henegouwen PM, Vonk AM, Rottier PJ, Reggiori F, de Haan CA. Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4. Virology. 2014 458- 459:125-35. Link

2013

van der Sluijs P, Zibouche M, van Kerkhof P. Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes. Frontiers Immunol. 2013 18: 359. Link

2012

Elstak ED, Neeft M, Nehme NT, Callebaut I, de Saint Basile G, van der Sluijs P. Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane. Commun. Integr. Biol. 2012 5: 64-7. Link

Ivan V, Martinez Sanchez E, Sima L, Oorschot V, Klumperman J, Petrescu SM, van der Sluijs P. AP-3 and rabip4’ coordinately regulate spatial distribution of lysosomes. PLoS One. 2012 7: e48142. Link

2011

Elstak ED, Neeft M, Nehme NT, Voortman J, Cheung M, Goodarzifard M, Gerritsen HC, van Bergen en Henegouwen PMP, Callebaut, I, de Saint Basile G, van der Sluijs P. The Munc13-4 rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood 2011 118: 1570-8. Link

Elstak ED, te Loo M, Tesselaar K,van Kerkhof P, Loeffen J, Grivas D, Hennekam E, Boelens JJ, Hoogerbrugge PM, van der Sluijs P, van Gijn ME, van de Corput L. A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function. Ped. Blood Cancer 2011 58: 598-605. Link

Grigoriev I, Yu KL, Martinez-Sanchez E, Serra Marques AA, Keijzer N, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, and Akhmanova A. Rab6, Rab8 and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. Curr. Biol. 2011 21: 967-74. Link

van der Sluijs P, Hoogenraad CC. New insights in endosomal dynamics and AMPA receptor trafficking. Semin. Cell Dev. Biol 2011 22: 499-505. Link

Elstak EDR, de Jong A, van der Sluijs P. A platform for complementation and characterization of familial haemophagocytic lymphohistiocytosis 3 mutations. J. Immunol. Meth. 2011 365: 58-66. Link

2010

Fraile-Ramos A, Cepeda V, Elstak EDR, van der Sluijs P. Rab27a is required for human cytomegalovirus assembly. PLoS One 2010 5: e15318. Link

Martinez Sanchez E, Popa I, Deneka M, van der Sluijs P. Role of rab4 in transport through the endosomal system. Rab GTPases and Membrane Trafficking 2010. 108-22 Link

Hoogenraad CC, van der Sluijs P. GRASP-1 regulates endocytic receptor recycling and synaptic plasticity. Commun. Integr. Biol. 2010 3:5, 1-3. Link

Ivan V, van der Sluijs P. Sorting and transport of melanosomal enzymes between post Golgi compartments. Rom. J. Biochem. 2010 47: 179-91.

Hoogenraad CC, Popa I, Futai K, Sanchez-Martinez E, Wulf PS, van Vlijmen T, Dortland BR, Oorschot V, Govers R, Monti M, Heck AJR, Sheng M, Klumperman J, Rehmann H, Jaarsma D, Kapitein LC, van der Sluijs P. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol. 2010 8: e1000283. Link

2009

Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS. Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J. Biol. Chem. 2009 285: 7794-8004. Link

Savelkoul PJ, De Mattia F, Li Y, Kamsteeg EJ, Konings IB, van der Sluijs P, Deen PM. P.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation. Hum Mutat. 2009 10: 681-93. Link

van Balkom BWM, Boone M, Hendriks G, Kamsteeg EJ, van der Voorde A, van Herp F, van der Sluijs P, Deen PMT. LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation. J. Am. Soc. Nephrol. 2009 20: 990-1001. Link

2008

Rojas R, van Vlijmen T, Mardones GA, Prabhu Y, Rojas AL, Mohammed S, Heck AJR, Raposo G, van der Sluijs P, Bonifacino JS. Regulation of retromer recruitment to endosomes by sequential action of rab5 and rab7. J. Cell Biol. 2008 183: 513-26. Link

van Vlijmen T, Vleugel M, Evers N, Mohammed S, Wulf P, Heck AJR, Hoogenraad C, van der Sluijs P. A unique residue in rab3 determines the interaction with novel binding protein Zwint-I. FEBS Lett. 2008 582: 2838-42. Link

Fila C, Metz C, van der Sluijs P. Juglone inactivates cysteine-rich proteins required for progression through mitosis. J. Biol. Chem. 2008 283: 21714-24. Link

Ahmed BA, Jeffus BC, Bukhari SI, Harney JT, Unal R, Lupashin VV, van der Sluijs P, Kilic F. Serotonin transamidates rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol. Chem. 2008 283: 9388-98. Link

van der Sluijs P, Neeft M, van Vlijmen T, Elstak E, Wieffer M. Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells. Meth. Enzymol. 2008 438: 185-201. Link

Kamsteeg EJ, Savelkoul PJ, Hendriks G, Konings IB, Nivillac NM, Lagendijk AK, van der Sluijs P, Deen PM. Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258. Pflugers Arch. 2008 455: 1041-54. Link

2006

Linder MD, Uronen RL, Vuori MH, van der Sluijs P, Peränen J, Ikonen E. Rab8- dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol. Biol. Cell. 2006 18, 47-56. Link

Kamsteeg EJ, Hendriks G, Konings IBM, Oorschot V, van der Sluijs P, Klumperman J, Deen PMT. Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc. Natl. Acad. Sci. USA. 2006 103, 18344-9. Link

2005

de Mattia F, Savelkoul PJM, Kamsteeg, EJ, Konings IBM, van der Sluijs P, Mallmann R, Oksche A, Deen PMT. Lack of arginine vasopressin-induced phosphorylation of Aquaporin-2 mutant AQP2-R254L explains dominant Nephrogenic Diabetes Insipidus. J. Am. Soc. Nephrol. 2005 16, 2872-80. Link

Popa I, Deneka M, van der Sluijs P. Expression and properties of the Rab4, Rabaptin-5alpha, AP-1 complex in endosomal recycling. Meth. Enzymol. 2005 403, 526-40. Link

Romijn EP, Christis C, Wieffer M, Gouw JW, Fullaondo A, van der Sluijs P, Braakman I, Heck AJ. Expression clustering reveals detailed co-expression patterns of functionally related proteins during B cell differentiation: a proteomic study using a combination of one-dimensional gel electrophoresis, LC-MS/MS, and stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics. 2005 4(9):1297-310. Link

2004

Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz C, van Loon A, Krijgsveld J, Griffith J, Wulffraat N, Koch H, Heck A, Brose N, Kleijmeer M, van der Sluijs P. Munc13-4 is an effector of rab27a and controls secretion of lysosomes in haematopoietic cells. Mol. Biol. Cell 2004 15, 731-41. Link

de Mattia F, Savelkoul PJM, Bichet, D, Kamsteeg, EJ, Konings IBM, Marr, N, Arthus MF, Lonergan MF, van Os, CH, van der Sluijs P, Robertson G, Deen PMT. A novel mechanism in recessive Nephrogenic Diabetes Insipidus: wild-type Aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L. Hum. Mol. Genet. 2004 13, 3045-56. Link

de Graaf P, van Dijken RAJ, Zwart W.T. Deneka M, Schulz TKF, Geijsen N, Coffer PJ, Gadella BM, Verkleij AJ, van der Sluijs P, van Bergen en Henegouwen PMP. Phosphatidylinositol-4-OHkinasebeta binds to and is critical for rab11-association with the Golgi complex. Mol. Biol. Cell 2004 15, 2038-47. Link

van Balkom BW, Graat MP, van Raak M, Hofman E, van der Sluijs P, Deen PM. Role of cytoplasmic termini in sorting and shuttling of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2004 286(2):C372-9. Link

Roberts M, Woods AJ, van der Sluijs P, Norman JC. Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins.. Mol. Cell Biol. 2004 24, 1505-15. Link

Hendriks G, Koudijs M, van Balkom BWM, Oorschot V, Klumperman J, Deen PMT, van der Sluijs P. Glycosylation is essential for cell surface expression of the water channel aquaporin-2, but not for its tetramerization in the endoplasmic reticulum. J. Biol. Chem. 2004 279, 2975-83. Link

Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJM. rabip4′ is an effector of rab5 and rab4 and regulates transport through early endosomes. Mol. Biol. Cell 2004 15, 611-24. Link

2003

Deneka M, Neeft M, Popa I, van Oort M, Sprong H, Oorschot V, Klumperman J, Schu P, van der Sluijs P. rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and g1-adaptin in membrane recycling from endosomes. EMBO J. 2003 22, 2645-57. Link

Sprong H, Degroote S, Nilsson T, Kawakita M, Ishida N, van der Sluijs P, van Meer G. Association of the UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. Mol. Biol. Cell 2003 14, 3482-93. Link

Deneka M, Neeft M, van der Sluijs P. Regulation of membrane transport by rab GTPases. Crit. Rev. Biochem. Mol. Biol. 2003 38, 121-42. Link

van Balkom BWM, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PMT. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J. Biol. Chem. 2003 278, 1101-7. Link

2002

van Balkom BWM, Savekoul PJM, Markovich D, Hofman E, Nielsen S, van der Sluijs P, Deen PMT. The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel. J. Biol. Chem. 2002 277, 41473-9. Link

Nellist M, Goedbloed MA, de Winter C, Verhaaf B, Jankie A, Reuser AJJ, van den Ouweland AMW, van der Sluijs P, Halley DJJ. Identification and characterization of the interaction between tuberin and 14-3-3zeta. J. Biol. Chem. 2002 277, 39417-24. Link

Mohrmann K, Gerez L, Oorschot V, Klumperman J, van der Sluijs P. Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle. J. Biol. Chem. 2002 277, 32029- 35. Link

Mohrmann K, Leijendekker R, Gerez L, van der Sluijs P. Rab4 regulates transport to the apical plasma membrane in Madin-Darby Canine Kidney cells. J. Biol. Chem. 2002 277: 10474-81. Link

Govers R, van der Sluijs P, Donselaar E, Slot JW, Rabelink TJ. Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinulear organelles. J. Histochem. Cytochem. 2002 50: 779-88. Link

Deneka M, van der Sluijs P. ‘Rab’ing up endosomal membrane transport.. Nature Cell Biol. 2002 4, E32-5. Link

2001

Sprong H, Hirabayashi Y, Westerink B, Oorschot V, Klumperman J, van der Sluijs P, van Meer G. Ceramide glucosyltransferase is required in sorting tyrosinase from the Golgi complex to melanosomes. J. Cell Biol. 2001 155: 369-79. Link

Roberts M, Barry S, Woods A, van der Sluijs P, Norman J. PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr. Biol. 2001 11: 1392-1402. Link

de Wit H, Lichtenstein Y, Kelly R, Geuze HJ, Klumperman J, van der Sluijs P. Rab4 enhances synaptic vesicle formation from early endosomes in PC12 cells. Mol. Biol. Cell 2001 12: 3703-15. Link

Sprong H, van der Sluijs P, van Meer G. How proteins move lipids and lipids move proteins. Nature Revs. Mol. Cell Biol. 2001 2: 504-14. Link

Deneka M, Negroiu G, van der Sluijs P. Pigmentation defects uncover a new function for rabs in organelle transport: rab27a in organelle motility. ELSO Gazette #4, 2001 Link

2000

van der Sluijs P, Mohrmann K, Deneka M, Jongeneelen M. Expression and properties of rab4 and its effector rabaptin-4 in endocytic recycling. Meth. Enzymol. 2000 329: 111-9. Link

Gerez L, Mohrmann K, van Raak M, Lu KP, van der Sluijs P. Accumulation of rab4GTP in the Cytoplasm and Association with the Peptidyl-Prolyl Isomerase Pin1 during Mitosis. Mol. Biol. Cell 2000 11: 2201-11. Link

Nagelkerken B, van Anken E, Mohrmann K, Gerez L, van Raak M, van Uden N, Holthuizen J, Pelkmans L, van der Sluijs P. Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles. Biochem. J. 2000 346: 593-601. Link

Scheper W, Zwart R, van der Sluijs P, Annaert W, van Gool WA, Baas, F. Alzheimer’s PS1 is a putative membrane receptor for rab GDP dissociation inhibitor. Hum. Mol. Gen. 2000 9: 303-10. Link

1999

Sprong H, van Meer G, van der Sluijs P. Analysis of galactolipids and UDP-galactose: ceramide galactosyltransferase. Meth. Enzymol. 1999 311: 59-73. Link

Nellist M, Slegtenhorst M, van den Ouweland A, Halley D, van der Sluijs P. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin. J. Biol. Chem. 1999 274: 35647-52. Link

de Wit H, Lichtenstein Y, Kelly R, van der Sluijs P, Klumperman J. Synaptic Vesicles Form by Budding from Tubular Extensions of Sorting Endosomes in PC12 Cells. Mol. Biol. Cell 1999 10: 4163-76. Link

van der Sluijs P, Gerez, L. Rab GTPases as regulators of transport through endosomes. Protoplasma 1999 210: 1-10. Link

Mohrmann K, van der Sluijs P. Regulation of membrane transport through the endocytic pathway by rab GTPases. Mol. Membr. Biol. 1999 16: 81-8. Link

1998

Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P. Interactions between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum. Mol. Gen. 1998 7:1053-7. Link

Sprong H, Kruithof B, Leijendekker R, Slot JW, Van Meer G, van der Sluijs P. UDP-Galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. J. Biol. Chem. 1998 273: 25880-8. Link

Mulders SM, Bichet DG, Rijs JPL, Kamsteeg EJ, Arthus MF, Lonergan M, Fujiwara M, Morgan K, Leijendekker RLL, van der Sluijs P, van Os CH, Deen PMT. An aquaporin-2 water channel mutant which causes autosomal nephrogenic diabetes insipidus is retained in the Golgi complex. J. Clin. Invest. 1998 102: 57-66. Link

1997

Chavrier P, van der Sluijs P, Nagelkerken B, Gorvel JP. Early endosome membrane dynamics characterized by flow cytometry. Cytometry 1997 29(1): 41-9. Link

Nagelkerken B, Mohrmann K, Gerez L, Van Raak M, Leijendekker R, van der Sluijs P. A novel epitope tag for the detection of rab GTPases. Electrophoresis 1997 18(14): 2694-8. Link

1996

Bottger G, Nagelkerken B, van der Sluijs P. Rab4 and rab7 define distinct, nonoverlapping endosomal compartments. J. Biol. Chem. 1996 271(46): 29191-7. Link

Elgersma Y, Vos A, van den Berg M, Roermund CWT, van der Sluijs P, Distel B, Tabak HF. Analysis of the carboxyterminal peroxisomal targeting signal in a homologous context in Saccharomyces cerevisiae. J. Biol. Chem 1996. 271(42): 26375-82. Link

Daro E, van der Sluijs P, Galli T, Mellman I. Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling. Proc. Natl. Acad. Sci. USA. 1996 93(18): 9559-64. Link

1994

van der Sluijs P. The small GTPase rab4 and membrane transport. GTPase controlled molecular machines. 1994 271-83.

1993

van der Sluijs P, Hull M, Mellman I. The small GTPase Rab4 controls an early endocytic sorting event. Molecular mechanisms of membrane transport. 1993 399-402. Link

1992

van der Sluijs P, Hull M, Webster P, Male P, Goud B, Mellman I. The small GTP binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 1992 70(5):729-40. Link

van der Sluijs P, Hull M, Huber L, Male P, Goud B, Mellman I. Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle. EMBO J. 1992 11(12): 4379-89. Link

1991

van der Sluijs P, Hull M, Zahraoui A, Tavitian A, Goud B, Mellman I. The small GTP-binding protein rab4 is associated with early endosomes. Proc. Natl. Acad. Sci. USA. 1991 88:6313-7. Link

van der Sluijs P, Meijer DKF. Limitations on the specificity of targeting asialoglycoprotein conjugates to the liver. Targeted diagnosis of liver diseases: cell surface receptors and directed agents. 1991 Chapter 11:235-64.

1990

van der Sluijs P, Bennett MK, Anthony C, Simons K, Kreis TE. Binding of exocytic vtransport vesicles from MDCK cells to microtubules in vitro. J. Cell Sci. 1990 95:545-53. Link

1989

Meijer DKF, van der Sluijs P. Binding of drugs to alpha-1-acid glycoprotein and its desialylated form. Influence on hepatic disposition an implications for drug targeting to the liver. Progr. Clin. Biol. Res. 1989 300:143-67.

Meijer DKF, van der Sluijs P. Covalent and noncovalent binding of drugs: implications for hepatic clearance, storage and cell-specific drug delivery. Pharm Res. 1989 6(2):105-18. Link

1988

van der Sluijs P, Braakman I, Meijer DK, Groothuis GM. Heterogeneous acinar localization of the asialoglycoprotein internalization system in rat hepatocytes. Hepatology. 1988 8(6):1521-9. Link

1987

Meijer DKF, van der Sluijs P. The influence of binding to albumin and alpha-1-acid glycoprotein on the clearance of drugs by the liver. Pharm Weekbl, Sci Ed. 1987 9(2): 65-74. Link

van der Sluijs P, Spanjer HH, Meijer DKF. Hepatic disposition of cationic drugs bound to asialoorosomucoid: lack of co-endocytosis and evidence for intrahepatic dissociation. J. Pharmacol. Exp. Ther. 1987 240(2): 668-73. Link

van der Sluijs P, Postema B, Meijer DKF. Lactosylation of albumin reduces the uptake rate of dibromosulphthalein in perfused liver, and dissociation rate from albumin in vitro. Hepatology 1987 7(4): 688-95. Link

1986

van der Sluijs P, Bootsma HP, Postema B, Moolenaar F, Meijer DKF. Drug targeting to the liver with lactosylated albumins: does the glycoprotein target the drug or is the drug targeting the glycoprotein. Hepatology 1986 6(4):723-8. Link

1985

van der Sluijs P, Meijer DKF. Binding of drugs with a quaternary ammonium group to alpha-1-acid glycoprotein and asialo alpha-1-acid glycoprotein. J. Pharmacol. Exp. Ther. 1985 234(3): 703-7. Link

van der Sluijs P, Oosting R, Weitering JG, Hardonk MJ, Meijer DKF. Biliary excretion of FITC metabolites after administration of FITC labeled asialoorosomucoid as a measure of lysosomal proteolysis. Biochem. Pharmacol. 1985 34(9):1399-405. Link